I have a question for running 100LL avgas

What jetting do you recommend for it.  I have a Paul Turner Pipe and Fat Boy 2 silencer.  A set of Boyseen Reeds and a aftermarket foam air filter in the stock airbox.  I was thinking about running it with the airbox lid off.

For the price of 94 at the local sunoco.. For an additional $1 per gallon more I could run the 100LL.  My premix will be 32:1 Klotz.

Is the extra work for the 100LL worth it over 94 at the Sunoco?

You will NEVER hurt an engine by running fuel with a higher octane fuel than what the engine requires.  Fuel with a higher octane than what your engines build requires is often cheap insurance against detonation if atmospheric conditions change a little or your speed drops to a crawl for a few minutes that cause the engine temperatures to go extremely high.

Most pistons will not usually have a heat related failure if you can prevent the engine from experiencing detonation and keep the coolant in the engine.