So in theory then, if a person cryo'd a wiseco piston....it should hold up a little longer right? Here's what's floating around in my head....if you cryogenic something,  you are basically aligning its molecules closer together right?  That's where the strength comes from?  So if they are closer, wouldn't this change the size of the object as minuscule as it may be?

Heat treating always alters the shape of the part being heat treated.  Cryo is just another form of heat treating.  Any form of heat treating will not WILL NOT FIX THE DESIGN PROBLEM associated with large bore forged pistons!